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Methods in Molecular Biophysics: Structure, Dynamics, Function, by Igor N. Serdyuk, Nathan R. Zaccai, Joseph Zaccai
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Our knowledge of biological macromolecules and their interactions is based on the application of physical methods, ranging from classical thermodynamics to recently developed techniques for the detection and manipulation of single molecules. These methods, which include mass spectrometry, hydrodynamics, microscopy, diffraction and crystallography, electron microscopy, molecular dynamics simulations, and nuclear magnetic resonance, are complementary; each has its specific advantages and limitations. Organised by method, this textbook provides descriptions and examples of applications for the key physical methods in modern biology. It is an invaluable resource for undergraduate and graduate students of molecular biophysics in science and medical schools, as well as research scientists looking for an introduction to techniques beyond their specialty. As appropriate for this interdisciplinary field, the book includes short asides to explain physics aspects to biologists and biology aspects to physicists.
- Sales Rank: #1257070 in eBooks
- Published on: 2007-03-29
- Released on: 2007-03-29
- Format: Kindle eBook
Review
"A book that teaches the methods well, creates the intellectual framework of our understanding, and can guide the field. Earlier efforts by Cohn and Edsall, Tanford, Edsall and Wyman, and Cantor and Schimmel have served this important purpose in the past, but the advance of time and technology has diluted the force of these classic works in contemporary Biophysics, both in the teaching and the practices of the field. How welcome, then, a clearly written, thoughtful and modern text that will serve well, both in formal courses and as a reference. The authors have built each method from its fundamental premises and principles, have successfully covered an impressive span of topics, and will be rewarded by attention from an audience that hungers for the next defining text in Molecular Biophysics."
D.M. Engelman, Yale University, New Haven, August 2005
"...a valuable contribution to the field. ... There is nothing quite like it at the moment."
Sir Tom Blundell FRS, FMedSci , Professor and Head, Department of Biochemistry, University of Cambridge
"... one of the most comprehensive and highly relevant texts on biophysics that I have encountered in the last 10 years, clearly written and up-to-date. ... a must-have for biophysicists working in all lines of research ..."
Nikolaus Grigorieff, Professor of Biochemistry, Brandeis University
"... a wonderful up-to-date treatise on the many and diverse methods used ... in the fields of molecular biophysics, physical biochemistry, molecular biology, biological physics and the new and emerging field of quantum nanobiology."
Karl J. Jalkanen, Associate Professor of Biophysics, Quantum Protein Centre, Technological University of Denmark
"... a valuable resource for novice and seasoned biophysicists alike."
Dan Minor, California Institute for Quantitative Biomedical Research University of California, San Francisco
"... the book I consult first when faced with an unfamiliar experimental technique. Both classic analytical techniques and the latest single-molecule methods appear in this single comprehensive reference."
Philip Nelson, Department of Physics, University of Pennsylvania, and author of Biological Physics (2004)
"... valuable both for students and research scientists."
Michael G. Rossmann, Hanley Professor of Biological Sciences, Purdue University
"A great achievement ... awaits the student who reads this book ... an excellent reference for the seasoned practitioner of biophysical chemistry."
Milton H Werner, Laboratory of Molecular Biophysics, The Rockefeller University
"This well written, thorough, and elegantly illustrated book provides the connections between molecular biophysics and biology that every aspiring young biologist needs."
Stephen H. White, Department of Physiology and Biophysics, University of California at Irvine
"... I enthusiastically recommend Methods in Molecular Biophysics to anyone who wishes to know more about the techniques by which the properties of biological macromolecules are determined."
David Worcester, Department of Biological Sciences, University of Missouri - Columbia
About the Author
Igor N. Serdyuk is Professor of Molecular Biology and Head of the Laboratory of Nucleoprotein Physics at the Institute of Protein Research, Pushchino, Russia.
Nathan R. Zaccai is a research associate at the Department of Chemical Engineering, University of Cambridge.
Jospeh Zaccai is Senior Fellow for Biology at the Institut Laue-Langevin and Directeur de Recherche of the Centre Nationale de la Recherche Scientifique.
Most helpful customer reviews
11 of 11 people found the following review helpful.
Great coverage, needs work though
By James
This is an excellent text in terms of covering the various techniques used in the field. Compared with other similar texts, this one includes mostly everything you'd ever want to know about and goes into good depth on its topics.
That being said, much like other books covering the same subject, this just doesn't feel finished. The book is sometimes brief when it should be explanatory and precise, and its explanations of the science behind the techniques sometimes leave out key logical steps. In its rush to get to complexities in the techniques, it neglects to give concrete examples of the basics. The thermodynamics sub-chapters covering ITC and DSC, for instance, do not spend enough time explaining the basics of how these instruments actually translate their raw data, in the form of graphs, into thermodynamic values. With the relative vacuum of books on these topics, these sorts of things become important - adding a well-labeled diagram and a paragraph or so would not bloat the book too much.
These problems, however, are a common occurrence in textbooks in this field. The competition is not very competitive. In the end, the respectable scope and depth of this book brings it to the front of its rather lackluster pack. Recommended, but I wish there was something better.
0 of 10 people found the following review helpful.
NEVER AGAIN
By J. Forson
I had no clue what this textbook was talking about in 99% of the chapters I read for school. It is more advanced book which we did not even use all that much. Unless you can share the cost with a friend by sharing the book, I don't recommend you buy it. Unless you love studying about the physics of molecules
0 of 10 people found the following review helpful.
In very good shape~
By Zheng Han
The book is good and it is like as said, almost new~ I am satisfied for this book~
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