Download The Organic Chemistry of Drug Design and Drug Action, by Richard B. Silverman
The Organic Chemistry Of Drug Design And Drug Action, By Richard B. Silverman. Learning how to have reading habit is like discovering how to try for eating something that you really do not desire. It will require even more times to aid. Additionally, it will also little make to serve the food to your mouth and ingest it. Well, as reviewing a book The Organic Chemistry Of Drug Design And Drug Action, By Richard B. Silverman, sometimes, if you need to read something for your new works, you will really feel so woozy of it. Also it is a book like The Organic Chemistry Of Drug Design And Drug Action, By Richard B. Silverman; it will certainly make you really feel so bad.
The Organic Chemistry of Drug Design and Drug Action, by Richard B. Silverman
Download The Organic Chemistry of Drug Design and Drug Action, by Richard B. Silverman
Why must pick the trouble one if there is easy? Get the profit by buying the book The Organic Chemistry Of Drug Design And Drug Action, By Richard B. Silverman here. You will get various method making a deal and also get the book The Organic Chemistry Of Drug Design And Drug Action, By Richard B. Silverman As recognized, nowadays. Soft data of guides The Organic Chemistry Of Drug Design And Drug Action, By Richard B. Silverman become popular with the readers. Are you among them? And below, we are providing you the extra collection of ours, the The Organic Chemistry Of Drug Design And Drug Action, By Richard B. Silverman.
Keep your means to be right here as well as read this page finished. You can take pleasure in browsing the book The Organic Chemistry Of Drug Design And Drug Action, By Richard B. Silverman that you really refer to obtain. Below, getting the soft documents of the book The Organic Chemistry Of Drug Design And Drug Action, By Richard B. Silverman can be done quickly by downloading in the link resource that we supply right here. Certainly, the The Organic Chemistry Of Drug Design And Drug Action, By Richard B. Silverman will certainly be all yours faster. It's no have to await the book The Organic Chemistry Of Drug Design And Drug Action, By Richard B. Silverman to obtain some days later on after purchasing. It's no should go outside under the heats at mid day to visit the book store.
This is some of the advantages to take when being the member and get guide The Organic Chemistry Of Drug Design And Drug Action, By Richard B. Silverman here. Still ask exactly what's various of the other site? We supply the hundreds titles that are produced by recommended writers and publishers, all over the world. The link to buy as well as download The Organic Chemistry Of Drug Design And Drug Action, By Richard B. Silverman is also extremely easy. You might not find the complex site that order to do even more. So, the method for you to obtain this The Organic Chemistry Of Drug Design And Drug Action, By Richard B. Silverman will be so very easy, won't you?
Based on the The Organic Chemistry Of Drug Design And Drug Action, By Richard B. Silverman specifics that we provide, you may not be so baffled to be below and to be member. Obtain currently the soft file of this book The Organic Chemistry Of Drug Design And Drug Action, By Richard B. Silverman and also save it to be your own. You conserving could lead you to evoke the simplicity of you in reading this book The Organic Chemistry Of Drug Design And Drug Action, By Richard B. Silverman Even this is kinds of soft data. You could really make better chance to get this The Organic Chemistry Of Drug Design And Drug Action, By Richard B. Silverman as the advised book to check out.
Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction.
* New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations
* Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years
* Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization
- Sales Rank: #1512918 in eBooks
- Published on: 2012-12-02
- Released on: 2012-12-02
- Format: Kindle eBook
Review
"...this text is directed towards graduates who are embarking on a career in medicinal chemistry in the discovery laboratory. Sliverman continues to blur the edges between chemistry and pharmacology in a manner that is incontrovertibly relevant to the discipline of drug design and development."
-Michael E. Cooper, GE Healthcare, The Maynard Centre, in DDT, VOL. 9, 2004
"What stands out in comparison with other books discussed here is that the subjects are generally addressed in detail, and each theoretical point is illustrated with examples of specific drugs. A great deal of knowledge is reflected...that is suitable for both advanced students and PhDs a like who have not yet become acquainted with the area, but who wish to prepare themselves for a career in drug research."
-ORGANIC CHEMISTRY ORG., 2005
Praise for the First Edition:
"This book is a tour de force in the title area...This book would be appropriate for advanced undergraduate students and graduate students...strongly recommended to scientists who are seeking an efficient introduction to medicinal chemistry, background in a specific drug principle or category, or a dose of inspiration."
--JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
"... unified, well-organized and clearly presented ...It is so clearly written that it will be of value to both students and veteran scientists...My congratulations to Dr. Silverman in consolidating such a multiplicity of facts and data so as to truly begin to reduce medicinal chemistry from a hybrid of chemistry, pharmacology and related sciences to a single, clearly defined, rationalized discipline."
--Carl Kaiser, Director of Medicinal Chemistry, NOVA PHARMACEUTICAL CORPORATION
"The author shows an uncanny ability to present the salient principles in a systematic, well-balanced and logical way..."
--William C. Groutas, WICHITA STATE UNIVERSITY
"I was favorably impressed with the clarity of Dr. Silverman's writing style which made the material interesting and easy to read...Treatment of the material is quite comprehensive without being overly detailed and the referencing and illustrations are well chosen..."
--John G. Topliss, PARKE-DAVIS
"...The organization of this book and the clarity of presentation are outstanding... It is highly recommended to medicinal chemists as well as to all others entering into the field or concerned with the science of medicinal chemistry."
--JOURNAL OF MEDICINAL CHEMISTRY
Praise for the new edition:
"...intent of the first edition was to provide a textbook for advanced undergraduate students or graduate students, the scope of the second edition has been expanded so that it not only serves the original purpose but also serves as an excellent reference book for practicing medicinal chemists."
--John W. Ellingboe, Wyeth Research for the Journal of Medicinal Chemistry, 2004
"...this book is a thorough overview of drug discovery and development... It is not only an excellent textbook for students but also a valuable resource for those already practicing medicinal chemistry."
John W. Ellingboe, Wyeth Research for the Journal of Medicinal Chemistry, 2004
From the Back Cover
This book provides a new approach to the teaching and understanding of medicinal chemistry. It is a survey of basic principles of drug design and drug action in which the concepts are presented from a physical organic chemistry perspective so that the design, development, and mechanisms of action and metabolism of drugs can be rationally understood. The reader is then able to apply these principles to any specific classes of drugs of interest and to understand how these drugs might act at a molecular level.
KEY FEATURES
*Provides an organic and synthetic chemist's perspective of how drugs are designed and how they function
*Teaches organic chemists and biochemists the fundamentals of drug design and drug action using drugs as examples
*No prior knowledge of biochemistry, pharmacology, or physiology is assumed
*Extensive use of references to the primary and secondary literature for more in depth reading about all concepts
*Extensive use of structures, schemes, and figures to illustrate points
*Problem sets and answers are included for each topic
*Informal but clear writing style so practicing chemists and undergraduates can easily understand the concepts presented
Richard B. Silverman is professor has published over 200 articles in the areas of synthesis, bioorganic chemistry, and medicinal chemistry, has been awarded 21 patents, and has invented a drug that is under consideration for commercialization.
About the Author
Professor Richard B. Silverman received his B.S. degree in chemistry from The Pennsylvania State University in 1968 and his Ph.D. degree in organic chemistry from Harvard University in 1974 (with time off for a two-year military obligation from 1969-1971). After two years as a NIH postdoctoral fellow in the laboratory of the late Professor Robert Abeles in the Graduate Department of Biochemistry at Brandeis University, he joined the chemistry faculty at Northwestern University. In 1986, he became Professor of Chemistry and Professor of Biochemistry, Molecular Biology, and Cell Biology. In 2001, he became the Charles Deering McCormick Professor of Teaching Excellence for three years, and since 2004 he has been the John Evans Professor of Chemistry. His research can be summarized as investigations of the molecular mechanisms of action, rational design, and syntheses of potential medicinal agents acting on enzymes and receptors.
His awards include DuPont Young Faculty Fellow (1976), Alfred P. Sloan Research Fellow (1981-1985), NIH Research Career Development Award (1982-1987), Fellow of the American Institute of Chemists (1985), Fellow of the American Association for the Advancement of Science (1990), Arthur C. Cope Senior Scholar Award of the American Chemical Society (2003), Alumni Fellow Award from Pennsylvania State University (2008), Medicinal Chemistry Hall of Fame of the American Chemical Society (2009), the Perkin Medal from the Society of Chemical Industry (2009), the Hall of Fame of Central High School of Philadelphia (2011), the E.B. Hershberg Award for Important Discoveries in Medicinally Active Substances from the American Chemical Society (2011), Fellow of the American Chemical Society (2011), Sato Memorial International Award of the Pharmaceutical Society of Japan (2012), Roland T. Lakey Award of Wayne State University (2013), BMS-Edward E. Smissman Award of the American Chemical Society (2013), the Centenary Prize of the Royal Society of Chemistry (2013), and the Excellence in Medicinal Chemistry Prize of the Israel Chemical Society (2014).
Professor Silverman has published over 320 research and review articles, holds 49 domestic and foreign patents, and has written four books (The Organic Chemistry of Drug Design and Drug Action is translated into German and Chinese). He is the inventor of LyricaTM, a drug marketed by Pfizer for epilepsy, neuropathic pain, fibromyalgia, and spinal cord injury pain; currently, he has another CNS drug in clinical trials.
Most helpful customer reviews
17 of 17 people found the following review helpful.
Outstanding...
By Ash Jogalekar
This is probably the best book of its kind in the vast and multidisciplinary field of drug design and action. Richard Silverman is an acclaimed chemistry professor at Northwestern University, and in this book he provides the most comprehensive and lucid exposition of the chemical basis of drug action that I have seen. No matter how complicated biological systems and their interactions are, at the basic level it's all chemistry, and mostly organic chemistry. Thus, understand the chemistry and you will go a long way in understanding drug action. An organic chemist will find this book extremely illuminating in a way that would not have been made clear through his or her traditional education.
The book opens with a short but clear discussion of drug discovery, combinatorial chemistry, patents and clinical trials. Then it leads the reader through a variety of enzyme catalyzed reactions, with examples of major drugs studded all the way. Silverman shows us how nature is the master organic chemist, employing the familiar reactions of chemistry in an unsurpassed manner. The chapter on enzyme inhibition is long and detailed and it's breathtaking. This is a key chapter because many major drugs act by inhibiting enzymes. The examples which Silverman chooses to illustrate are both important (including many bestselling anticancer, antiviral, and antibiotic drugs to name a few), as well as very interesting. The last parts of the book deal with DNA binding drugs and with pathways of drug metabolism and excretion. Along all the way, the emphasis is on the chemical reactions that drugs undergo, which are after all the key to understanding their properties. The lucidity of the book is such that a beginning graduate or advanced undergraduate well-versed with the basic principles of general and organic chemistry can easily understand all the contents.
I would say that this book is so interesting and illuminating that it's one of the very few academic books which you can enjoyably read cover to cover. In fact it even makes great bedside reading! Truly a must-have book for chemists and biologists of every kind interested in how drugs work.
2 of 2 people found the following review helpful.
Fantastic Book for chemists and medicinal chemists
By Eric Ballard
Some books of this nature tend to focus on the synthesis of drug molecules and less about how they work and why. This book is just the opposite and walks the reader through a logical progression of drug discovery, design and target specificity. This book makes a great introduction to Goodman & Gilman's The Pharmacological Basis of Therapeutics which could be considered the bible of the subject.
0 of 0 people found the following review helpful.
Excellent read compared to Foye
By RN
We use Foye for Pharmacy students and this text distinguishes itself by being an easier read and having more illustrative examples. That said, it won't replace the drug-class focused chapters in Foye, but this is a much better textbook for fundamentals of medicinal chemistry.
The Organic Chemistry of Drug Design and Drug Action, by Richard B. Silverman PDF
The Organic Chemistry of Drug Design and Drug Action, by Richard B. Silverman EPub
The Organic Chemistry of Drug Design and Drug Action, by Richard B. Silverman Doc
The Organic Chemistry of Drug Design and Drug Action, by Richard B. Silverman iBooks
The Organic Chemistry of Drug Design and Drug Action, by Richard B. Silverman rtf
The Organic Chemistry of Drug Design and Drug Action, by Richard B. Silverman Mobipocket
The Organic Chemistry of Drug Design and Drug Action, by Richard B. Silverman Kindle
Tidak ada komentar:
Posting Komentar